Both PRP (platelet rich plasma), and PRF (platelet rich fibrin) are platelet based growth factor treatments that are extracted using centrifuge. PRF is different from PRP in that there is no anticoagulant added during the spin, the avoidance of clotting is physiological and is achieved through negative charge of the collecting tube to mimic the conditions within our own blood vessels (their lining is negatively charged) that prevent fibrin from creating a clot within them, thus, obtaining a platelet rich injectable fibrin. Once PRF is injected in the tissue it transforms from liquid into a gel, which not only lead to filling of voids in folds and wrinkles but also provide a powerful regenerative matrix that releases platelets’ growth factors in a physiological controlled slow manner that enhances tissue regeneration is a better way than PRP.
In addition, the enrichment of platelets in these two products is not the same. In PRP, the platelets are enriched two to four times above the physiological concentrations available in blood and there are very few circulating blood stem cells. In contrast, PRF contains all the platelets with no elimination of the powerful regenerative matrix (fibrin) in addition to another very rich source of growth factors and tissue regeneration: the circulating blood stem cells.
YES. Injury to any human tissue (ageing is also injury) will immediately result in platelet growth factors in a fibrin scaffold are the first response to injury observed in all human tissue. Accelerated healing, new blood vessels and proliferation of cells producing collagen (fibroblasts) have been well demonstrated in biomedical research investigating the basic functions of this regenerative products. Even its predecessor – PRP – has been shown to significantly accelerate healing in tissues and is widely used in the aesthetic field too.
Dr Choukroun explains that Fibrin functions as a matrix that traps the platelets and controls their release of growth factors “very slowly and continuously over a time period of more than one week”. Growth factors release rate into the target tissue is important for tissue receptors to respond over a prolonged period of time following treatment. “It’s not the amount of growth factors that’s the most important, but it is released into the site. To treat severe infection, antibiotics can be injected drop by drop in an IV perfusion, ensuring that a stable concentration is maintained. This is the same in PRF biology—to obtain the most important function a stable concentration must be maintained. The best is a drop-by-drop infusion”
iPRF is a natural way to help male and female hair thinning. iPRF can enhance the growth of hair follicles by stimulating the stem cells and other cells in the microenvironment of the hair follicle. These special platelet cells promote healing and accelerate the rate and degree of tissue regeneration, resulting in new hair growth and thickening of existing hair.