How GLP-1 Medications Like Ozempic Affect Your Skin and Face — And What You Can Do About It

GLP-1 medications such as Ozempic, Wegovy, and Mounjaro are widely celebrated for their effects on weight loss and blood sugar control. However, their unexpected impact on skin health and facial appearance is less well known.

Rising Concerns: What Is “Ozempic Face”?

At Perfect Skin Solutions, we are seeing a rising number of patients concerned about “Ozempic face” — a term describing the rapid facial volume loss, skin sagging, and hollowed appearance some experience with GLP-1 agonists. So, what is really happening to your skin, and how can you restore a youthful look without compromising your weight loss goals?

What Are GLP-1 Medications, and How Do They Affect the Body?

GLP-1 (glucagon-like peptide-1) is a hormone that regulates blood sugar, appetite, and insulin secretion. Medications like Ozempic (semaglutide), Wegovy, and Mounjaro (tirzepatide) mimic this hormone to reduce hunger, improve glucose control, and promote significant weight loss.

However, rapid weight loss may lead to:

• Facial volume loss — including loss of fat that supports youthful contours

• Reduced dermal density — increasing lines, wrinkles, and sagging

• Muscle mass reduction — decreased facial muscle support

• Bone density loss — possible long-term changes to facial structure

These changes can accelerate visible aging, but they are not irreversible.

Understanding “Ozempic Face”: More Than Just Fat Loss

Facial volume is not only about fat. It also depends on collagen, elastin, hydration, and extracellular matrix (ECM) integrity — factors that can all be altered by the body’s metabolic changes.

Rapid weight loss can:

• Deplete ECM proteins

• Reduce growth factor signalling

• Disturb skin’s regenerative balance

Common visible effects:

• Crepey skin

• Deeper nasolabial folds and marionette lines

• Poor wound healing

• Dull, uneven tone/texture

This is where regenerative medicine helps not just at the skin’s surface, but biologically.

Regenerative Skin Support with Topical Therapy

CellDerma GF5 and Youth Restore

Topical therapy is a cost-effective daily support for skin health, especially alongside professional treatments.

Products like CellDerma GF5 and Youth Restore serums use a clinically active growth factor complex (EGF, IGF-1, FGF, VEGF) to:

• Boost fibroblast proliferation

• Stimulate collagen and elastin

• Enhance wound healing

• Improve hydration, barrier function, and resilience

Daily use is especially recommended for those on GLP-1 medications.

Advanced In-Clinic Treatments: Restore Volume, Structure, and Vitality

Perfect Skin Solutions offers comprehensive regenerative and collagen-stimulating therapies to address GLP-1-induced facial changes:

1. Skinova Elite (LDM Triple)

• Ultrasound technology supports dermal regeneration, stimulates ECM proteins, reduces inflammation, and improves hydration.

2. Microneedling with Growth Factors

• Creates micro-channels to enhance GF5 absorption, boosting fibroblast activity and repair.

3. Dermalux Triwave MD

• LED light therapy promotes cellular energy, collagen synthesis, and reduces inflammation, helping restore tone and elasticity.

4. Radiesse (Hyperdiluted)

• Biostimulant approach lifts and firms by stimulating natural collagen production—subtle, natural enhancement in cheeks, jaw, and neck.

5. Radiesse (Undiluted)

• Volumises and restores facial structure, especially effective for mid-face, temples, and jawline support.

The Bottom Line: Balance Weight Loss and Youthful Skin

GLP-1 medications are transformative, but their effects on skin deserve attention. With targeted regenerative therapies and daily topical support, you can restore facial balance and look as good as you feel.

If you’re noticing facial changes or want to be proactive while on Ozempic, Wegovy, or Mounjaro, we’re here to help.

Book Your Personalised Consultation Today

Call Perfect Skin Solutions on 02392 754 777 to book a consultation with our expert skin therapists or doctors. We’ll create a tailored plan to support your skin and face at every stage of your health journey.